top of page


The risk of contracting HIV and hepatitis B through occupational and non-occupational exposure, as well as the high incidence of unplanned pregnancies and sexual assault, mandated the development of an accessible and evidence-based post-exposure prophylaxis (PEP) guideline for South Africa.


The National Department of Health has published new PEP guidelines to ensure that a patient- centred, high-quality PEP service is available and that this service responds to the Criminal Law (Sexual Offences and Related Matters) Amendment Act 32 of 2007.


Course Goal

This course provides clinical guidance for clinicians and managers on the use of PEP for the prevention of HIV, hepatitis, unplanned pregnancies, STIs, and tetanus, within the context of a comprehensive care package that supports both the clinical and psychosocial aspects of post-exposure prophylaxis management.


Course Modules

  • Introduction to PEP
  • Epidemiology of Occupational and Non-Occupational Exposures to Blood Borne Infections.
  • Exposure, Risk & Transmission.
  • Management of potential exposure: Healthcare Providers, Sexual Assault and Pregnancy and breastfeeding.
  • PEP for HIV in Adults: PEP Eligibility, HIV Testing, consent, Regimen selection, counselling, and support.
  • PEP for HIV in Children: Sexual assault and Inadvertent exposure, Child ACT and consent for HIV Testing in children, PEP regimens for children, monitoring and support.
  • PEP for Hepatitis Prevention: Indications of HBV PEP, Timing and Effectiveness, Management of HBV and HCV exposures
  • PEP for STIs: Presumptive STI Treatment & Emergency Contraception
  • Pregnancy Prevention: Emergency Contraception
  • Tetanus Prevention: What is Tetanus infection and Tetanus PEP requirements.


Who should enroll?

Healthcare professionals registered with the relevant professional council.


Course design

The course is available via self-paced eLearning course, or an interactive contact class. This interactive training program is composed of video lectures, demonstrations, MCQ assessments, case studies and groupwork.



Self-paced: 2 weeks to complete the course.



Participants will be assessed on ongoing course exercises, pre and posttests and case studies.



To qualify for the certificate of completion for this short course, participants should fully attend the course fully as well as successfully complete the assessment process.



The training content is based on the National Department of Health National Clinical Guidelines of Post-Exposure Prophylaxis (PEP) in Occupational and Non-Occupational Exposures, South African Primary Healthcare Level Essential Medicines List (2019), the WHO PEP guidelines (2014) and the Southern African HIV Clinicians Society guidelines (2015). It is a critical component of healthcare worker Continuous Professional Development and accredited according to the HPCSA’s Medical and Dental Board Guidelines for Healthcare Professions for 6 CPD Points. The certificate will be available within 48 hours once the course is successfully completed.


Training includes:

  • Clinical Guidelines
  • Job aids
  • eLearning Instruction
  • Participant assessment and evaluation
  • Participant certification


To register please contact: 


Call/WhatsApp: 061 540 7952

PEP - Post Exposure Prophylaxis

    bottom of page